Huw Collingbourne, author of bitwise magazine but also Co-Founder of SapphireSteel Software just published an article showing how he integrated a Ruby back-end written in their excellent Ruby In Steel product with a Windows Forms front-end written in Chrome.
I’m not a Ruby guy myself (again and again simply not finding the time to check out what i am sure is a very interesting and promising language) but from what i can tell, SapphireSteel’s Ruby In Steel, which (like Chrome) integrates into Visual Studio 2005, is definitely the way to g0 for Ruby development – and if it works well with Chrome, all the better! 
Check out the full story at http://www.sapphiresteel.com/Ruby-In-Chrome.
